Confirmed RA variants

List of RA associated SNPs/variants that were reproduced by independent studies. The association results of the genetic variant listed here is a result of the study using the largest samples and satisfied the P value < 0.05 and 1.0 x 10-5 for candidate gene association studies and genome-wide association studies, respectively. To see all association results of the particular variant or gene, click the name of the variant or gene.

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refSNP(s):

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Reproducibility Ethnic
population
Genes Genetic variant (allele) Allele
P value
Odds
ratio
EAF
case / ctrl
Title/Reference/text-mining Case/control samples Sample Countries Case description Control description study platform/snp_size reproducibility
Inter-population European HLA-DRB1 [29/34] rs6457617 (T) [2/2] 3.44e-76    0.69 / 0.49 "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls." WTCCC, Nature, 2007 (Sup Table 10). [ Show all associations ] [ PubMed ] 1861 / 2938 United Kingdom of Great Britain and Northern Ireland Cases from NHS Rheumatology Clinics throughout the UK; age 18<; fulfilled ACR 1987 (WTCCC) Controls from 1958 Birth Cohort Controls and UK Blood Services Controls; Age 18-70 GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Affymetrix 500K (469557 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population European HLA-DRB1 [29/34] rs6457620 (G) [2/2] 3.6e-186  2.55  0.72 / 0.50 "Common variants at CD40 and other loci confer risk of rheumatoid arthritis." Raychaudhuri S, Nat Genet, 2008 (Sup Table S-1). [ Show all associations ] [ PubMed ] 3393 / 12462 North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases from WTCCC, NARAC, EIRAC Controls from WTCCC, NARAC, EIRAC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 500K platform (336721 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European PTPN22 [17/22] rs6679677 (-) [2/2] 5.7e-42  1.79  0.17 / 0.10 "Common variants at CD40 and other loci confer risk of rheumatoid arthritis." Raychaudhuri S, Nat Genet, 2008 (Sup Table S-1). [ Show all associations ] [ PubMed ] 3393 / 12462 North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases from WTCCC, NARAC, EIRAC Controls from WTCCC, NARAC, EIRAC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 500K platform (336721 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CD40 [9/9] rs1569723 (C) [2/2] 3.2e-07  0.83  0.22 / 0.25 "Common variants at CD40 and other loci confer risk of rheumatoid arthritis." Raychaudhuri S, Nat Genet, 2008 (Sup Table S-1). [ Show all associations ] [ PubMed ] 3393 / 12462 North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases from WTCCC, NARAC, EIRAC Controls from WTCCC, NARAC, EIRAC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 500K platform (336721 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European MMEL1, TNFRSF14 [8/8] rs6684865 (G) [2/2] 5.9e-06  0.86  0.30 / 0.33 "Common variants at CD40 and other loci confer risk of rheumatoid arthritis." Raychaudhuri S, Nat Genet, 2008 (Sup Table S-1). [ Show all associations ] [ PubMed ] 3393 / 12462 North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases from WTCCC, NARAC, EIRAC Controls from WTCCC, NARAC, EIRAC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 500K platform (336721 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CDK6 [2/5] rs42041 (G) [2/5] 4e-06  1.11  0.28 / 0.25 "Common variants at CD40 and other loci confer risk of rheumatoid arthritis." Raychaudhuri S, Nat Genet, 2008 (Sup Table S-2). [ Show all associations ] [ PubMed ] 7322 / 18267 Netherlands, North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cohort 1 (3393 cases from WTCCC, NARAC and EIRAC) and cohort 2 (3,929 cases; with CCP or RF positiive; from NHS, BRASS, NARAC, GCI, LUMC, EIRA, GENRA) Combination of cohort 1 (12460 controls from WTCCC, NARAC, and EIRAC) and cohort 2 (5,807 controls) (2) The association data validated by different genotyping platforms and different samples. Meta-analysis of selected SNPs (31 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European C5, TRAF1 [18/25] rs10985073 (A) [2/2] 9.1e-11  1.26  / "REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis." Gregersen PK, Nat Genet, 2009 (Sup). [ Show all associations ] [ PubMed ] 2418 / 4504 Canada, United States of America Cases with CCP+; derived in part from affected sibling pair families of NARAC (one case per family) Controls from NARAC GWAS: Genome-wide association study. (4) The association data validated by different samples Illumina HapMap370 BeadArray typing platforms (278502 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European C5, TRAF1 [18/25] rs881375 (A) [2/2] 5.48e-10  1.26  / "REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis." Gregersen PK, Nat Genet, 2009 (Sup). [ Show all associations ] [ PubMed ] 2418 / 4504 Canada, United States of America Cases with CCP+; derived in part from affected sibling pair families of NARAC (one case per family) Controls from NARAC GWAS: Genome-wide association study. (4) The association data validated by different samples Illumina HapMap370 BeadArray typing platforms (278502 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European C5, TRAF1 [18/25] rs7037673 (A) [2/2] 4.6e-08  0.84  / "REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis." Gregersen PK, Nat Genet, 2009 (Sup). [ Show all associations ] [ PubMed ] 2418 / 4504 Canada, United States of America Cases with CCP+; derived in part from affected sibling pair families of NARAC (one case per family) Controls from NARAC GWAS: Genome-wide association study. (4) The association data validated by different samples Illumina HapMap370 BeadArray typing platforms (278502 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European REL [9/9] rs13017599 (A) [3/3] 2.6e-12  1.21  0.39 / 0.34 "REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis." Gregersen PK, Nat Genet, 2009 (Result). [ Show all associations ] [ PubMed ] 5022 / 7386 Canada, United States of America Combination of cohort 1 (2418 cases with CCP+) and cohort 2 ( 2,604 Cases) Combination of cohort 1 (4504 controls) and cohort 2 (2,882 controls) (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (4 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CTLA4, ICOS [11/17] rs231735 (G) [2/2] 6.25e-09  0.86  0.44 / 0.49 "REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis." Gregersen PK, Nat Genet, 2009 (Result). [ Show all associations ] [ PubMed ] 5022 / 7386 Canada, United States of America Combination of cohort 1 (2418 cases with CCP+) and cohort 2 ( 2,604 Cases) Combination of cohort 1 (4504 controls) and cohort 2 (2,882 controls) (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (4 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population East Asian HLA-DRB1 [23/36] rs13192471 (G) [2/2] 1.9e-58  1.97  0.36 / 0.22 "A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility." Kochi Y, Nat Genet, 2010 (Sup Table 2). [ Show all associations ] [ PubMed ] 2303 / 3380 Japan Cases were female 81.4%; age 61.4+-11.5; with 75.7% RF positive; with 79.2% positive; from BioBank Japan and IORRA of Tokyo Women's Medical University Controls were female 44.4%; age 52.5+-15.2, from BioBank Japan and IORRA GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina Human Hap610-Quad (550000 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population East Asian CCR6 [5/8] rs3093024 (T) [3/4] 7.7e-19  1.19  0.51 / 0.46 "A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility." Kochi Y, Nat Genet, 2010 (Sup Table 4, Result). [ Show all associations ] [ PubMed ] 7069 / 15876 Japan Combination of cohort 1 (2,303 cases), cohort 2 (3,662 cases) and cohort 3 (1,106 cases) Combination of cohort 1 (3,380 controls), cohort 2 (15,873 controls) and cohort 3 (1,486 controls) (2) The association data validated by different genotyping platforms and different samples. CCR6 and RA associated SNPs (13 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population East Asian STAT4 [13/18] rs7574865 (T) [6/9] 1.8e-06  1.17  0.36 / 0.33 "A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility." Kochi Y, Nat Genet, 2010 (Sup Table 4, Result). [ Show all associations ] [ PubMed ] 7069 / 15876 Japan Combination of cohort 1 (2,303 cases), cohort 2 (3,662 cases) and cohort 3 (1,106 cases) Combination of cohort 1 (3,380 controls), cohort 2 (15,873 controls) and cohort 3 (1,486 controls) (2) The association data validated by different genotyping platforms and different samples. CCR6 and RA associated SNPs (13 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 6 out of 9 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian OLIG3, TNFAIP3 [7/10] rs2230926 (C) [3/3] 1.6e-06  1.31  0.09 / 0.07 "A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility." Kochi Y, Nat Genet, 2010 (Sup Table 4, Result). [ Show all associations ] [ PubMed ] 7069 / 15876 Japan Combination of cohort 1 (2,303 cases), cohort 2 (3,662 cases) and cohort 3 (1,106 cases) Combination of cohort 1 (3,380 controls), cohort 2 (15,873 controls) and cohort 3 (1,486 controls) (2) The association data validated by different genotyping platforms and different samples. CCR6 and RA associated SNPs (13 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 3 association results.
The variant is confirmed between different ethnic populations.
Inter-population European HLA-DRB1 [29/34] rs6910071 (G) [2/2] 1e-299  2.88  0.44 / 0.22 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 1A). [ Show all associations ] [ PubMed ] 5539 / 20169 Canada, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases with CCP positive; from BRASS, CANADA, EIRA, NARAC, WTCCC Controls from BRASS, CANADA, EIRA and WTCCC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 6.0, Illumina 370K, Illumina 317K, Illumina 500K, Affymetrix 500K (2554714 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population European C5, TRAF1 [18/25] rs3761847 (G) [4/5] 2.1e-07  1.13  0.46 / 0.43 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 1A). [ Show all associations ] [ PubMed ] 5539 / 20169 Canada, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases with CCP positive; from BRASS, CANADA, EIRA, NARAC, WTCCC Controls from BRASS, CANADA, EIRA and WTCCC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 6.0, Illumina 370K, Illumina 317K, Illumina 500K, Affymetrix 500K (2554714 SNPs) Among the studies for European population, a statistical significance was confirmed in 4 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European AFF3 [6/6] rs10865035 (A) [2/2] 2e-06  1.12  0.50 / 0.47 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 1A). [ Show all associations ] [ PubMed ] 5539 / 20169 Canada, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases with CCP positive; from BRASS, CANADA, EIRA, NARAC, WTCCC Controls from BRASS, CANADA, EIRA and WTCCC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 6.0, Illumina 370K, Illumina 317K, Illumina 500K, Affymetrix 500K (2554714 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European RBPJ [2/2] rs874040 (C) [2/2] 1e-16  1.16  0.34 / 0.30 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European AFF3 [6/6] rs11676922 (T) [2/2] 1e-14  1.14  0.49 / 0.46 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European ANKRD55, IL6ST [2/2] rs6859219 (A) [2/2] 9.6e-12  0.81  0.19 / 0.21 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European IL2RA [6/11] rs706778 (T) [2/2] 1.4e-11  1.12  0.44 / 0.41 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European CCR6 [2/2] rs3093023 (A) [2/2] 1.5e-11  1.12  0.47 / 0.43 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population European IRF5 [5/9] rs10488631 (C) [3/3] 4.2e-11  1.21  0.13 / 0.11 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CCL21 [6/8] rs951005 (G) [2/2] 3.9e-10  0.86  0.14 / 0.16 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European SPRED2 [2/2] rs934734 (G) [2/2] 5.3e-10  1.13  0.50 / 0.49 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population European C5orf30 [2/2] rs26232 (T) [2/2] 4.1e-08  0.90  0.30 / 0.32 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European PXK [2/2] rs13315591 (C) [2/2] 4.6e-08  1.20  0.10 / 0.09 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European BATF [2/2] rs7155603 (G) [2/2] 1.1e-07  1.14  0.22 / 0.20 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European IL2, IL21 [7/18] rs13119723 (G) [2/4] 6.8e-07  0.88  0.14 / 0.16 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed between different ethnic populations.
Inter-population European IKZF3 [2/4] rs2872507 (A) [2/4] 9.4e-07  1.09  0.48 / 0.47 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed between different ethnic populations.
Intra-population European UBASH3A [4/5] rs11203203 (A) [4/5] 3.8e-06  1.09  0.39 / 0.37 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 4 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European SH2B, SH2B3 [3/4] rs3184504 (C) [3/4] 6e-06  0.93  0.49 / 0.49 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 2 C). [ Show all associations ] [ PubMed ] 12307 / 28975 Canada, Netherlands, United Kingdom of Great Britain and Northern Ireland, United States of America Combination of cases with CCP or RF positive; from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, NARAC, UKRAG and NHS Combination of controls from BRASS, EIRA, WTCCC, CANADA, Dutch, GENRA, GCI, LUMC, UKRAG, and NHS (2) The association data validated by different genotyping platforms and different samples. Selected SNPs (34 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European DDX6 [2/2] rs10892279 (-) [2/2] 1.1e-08  0.87  / "Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci." Zhernakova A, PLoS Genet, 2011 (). [ Show all associations ] [ PubMed ] 8384 / 22175 North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Meta-analysis of PMID20453842 (5,539 cases with autoantibody positive) and 2,845 cases with autoantibody positive Meta-analysis of PMID20453842 (17,231 controls) and 2,845 controls (2) The association data validated by different genotyping platforms and different samples. RA associated SNPs (16 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European C5, TRAF1 [18/25] rs1953126 (-) [3/3] 5e-09  1.13  / "Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci." Zhernakova A, PLoS Genet, 2011 (). [ Show all associations ] [ PubMed ] 8384 / 22175 North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Meta-analysis of PMID20453842 (5,539 cases with autoantibody positive) and 2,845 cases with autoantibody positive Meta-analysis of PMID20453842 (17,231 controls) and 2,845 controls (2) The association data validated by different genotyping platforms and different samples. RA associated SNPs (16 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population East Asian HLA-DRB1 [23/36] rs2516049 (C) [1/1] 3.6e-31  2.18  0.38 / 0.22 "Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis-A Genome-Wide Study Combined with Immunological Analyses" Terao C, PLoS ONE, 2011 (sup. table 3). [ Show all associations ] [ PubMed ] 874 / 855 Japan 85.5% female, 62.6+-11.6 average age 39.6% female, 38.1+-11.9 average age GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Taqman (225079 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population European CD2, CD58, IGSF2 [3/4] rs11586238 (G) [3/4] 1e-09  1.13  0.26 / 0.23 "Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk" Raychaudhuri R, Nat Genet, 2009 (). [ Show all associations ] [ PubMed ] 11350 / 24420 Canada, Germany, North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America 100% CCP positive (2) The association data validated by different genotyping platforms and different samples. Bioinfomaticaly selected representative SNPs from previous GWAS meta-analysis (22 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CD28 [2/4] rs1980422 (C) [2/4] 1.3e-09  1.13  0.26 / 0.23 "Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk" Raychaudhuri R, Nat Genet, 2009 (). [ Show all associations ] [ PubMed ] 11350 / 24420 Canada, Germany, North America, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America 100% CCP positive (2) The association data validated by different genotyping platforms and different samples. Bioinfomaticaly selected representative SNPs from previous GWAS meta-analysis (22 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European CTLA4, ICOS [11/17] rs231775 (-) [1/2] 0.009  1.07  0.39 / 0.38 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 6160 / 6684 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 1 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population European C1QTNF6, IL2RB [2/4] rs743777 (-) [2/4] 1.44e-06  1.25  0.33 / 0.31 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 11038 / 10665 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CD226 [2/3] rs763361 (-) [2/3] 0.009  1.06  0.48 / 0.47 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 10254 / 10427 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European AFF3 [6/6] rs1160542 (-) [2/2] 1.15e-07  1.11  0.48 / 0.46 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 10902 / 11158 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European KIF5A, PIP4K2C [3/4] rs1678542 (-) [3/4] 3.64e-09  0.90  0.35 / 0.37 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 14378 / 17490 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European IL2RA [6/11] rs2104286 (-) [2/4] 2.48e-05  0.91  0.25 / 0.27 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 10112 / 10450 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed between different ethnic populations.
Intra-population European PTPN22 [17/22] rs2476601 (A) [10/11] 2.3e-98  1.60  0.15 / 0.10 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 20079 / 20673 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 10 out of 11 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CCL21 [6/8] rs2812378 (-) [4/6] 7.79e-07  1.09  0.36 / 0.34 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 14146 / 16975 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 4 out of 6 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European C5, TRAF1 [18/25] rs2900180 (-) [2/2] 6.5e-13  1.15  0.38 / 0.34 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 12357 / 13621 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CTLA4, ICOS [11/17] rs3087243 (-) [7/10] 4.08e-08  0.90  0.42 / 0.45 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 12372 / 13267 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 7 out of 10 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European PRKCQ [4/5] rs4750316 (-) [3/4] 1.54e-07  0.90  0.18 / 0.19 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 14306 / 17482 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European CD40 [9/9] rs4810485 (-) [6/6] 6.07e-10  0.89  0.23 / 0.25 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 14031 / 17016 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 6 out of 6 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European OLIG3, TNFAIP3 [19/27] rs5029937 (-) [2/2] 4.62e-10  1.42  0.05 / 0.03 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 7731 / 9403 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population European IL2, IL21 [7/18] rs6822844 (-) [4/7] 5.89e-08  0.88  0.16 / 0.18 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 12953 / 13370 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 4 out of 7 association results.
The variant is confirmed between different ethnic populations.
Intra-population European OLIG3, TNFAIP3 [19/27] rs6920220 (-) [10/11] 1.08e-15  1.18  0.23 / 0.20 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 14566 / 14415 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 10 out of 11 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European STAT4 [12/13] rs7574865 (-) [12/12] 2.99e-15  1.18  0.25 / 0.22 "Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers" Plant D, Ann Rheum Dis, 2010 (table 3). [ Show all associations ] [ PubMed ] 14394 / 16131 Denmark, France, Germany, Greece, Sweden, United Kingdom of Great Britain and Northern Ireland Data from 15 published studies and Plant 2010 (this study) Data from 15 published studies and Plant 2010 (this study) (2) The association data validated by different genotyping platforms and different samples. The SNPs associated with RA susceptibility (18 SNPs) Among the studies for European population, a statistical significance was confirmed in 12 out of 12 association results.
The variant is confirmed between different ethnic populations.
Intra-population European PODXL [2/2] rs11761231 (-) [2/2] 0.042  0.94  0.35 / 0.36 "Rheumatoid arthritis association at 6q23." Thomson W, Nat Genet, 2007 (table 1, sup. table 4). [ Show all associations ] [ PubMed ] 5063 / 3849 United Kingdom of Great Britain and Northern Ireland DNA from RA patients, over 18 years old and satisfying the American College of Rheumatology criteria for RA1 was available from 6 centres in the UK; male 33.8% and female 66.2%; RF positive 71.6%; Anti CCP positive 66.8%; SE carrier (1 copy) 49%; SE carrier (2 copies) 25.6%. Healthy controls from Manchester, Aberdeen, Leeds, Sheffield, London, Oxford. (5) The association data validated by only one genotyping platform and one sample. Susceptibility variant rs2476601, mapping to the PTPN22 gene, and nine previously unknown SNPs identified by the WTCCC study (13 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DPB1 [8/8] rs3117222 (T) [2/2] 3.83e-07    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DPB1 [8/8] rs2295118 (T) [2/2] 3.75e-08    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DPB1 [8/8] rs9277378 (G) [2/2] 3.09e-08    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DPB1 [8/8] rs9277463 (T) [2/2] 4.36e-09    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DRA [6/6] rs2395178 (G) [2/2] 7.57e-15    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DRA [6/6] rs2395173 (A) [2/2] 5.88e-15    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European APOM [8/8] rs805297 (A) [1/1] 1.49e-16    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population European C6orf10 [2/2] rs9296021 (T) [2/2] 1.71e-26    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European HLA-DRA [6/6] rs2227139 (G) [2/2] 8.41e-39    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European HLA-DRB1 [29/34] rs2516049 (C) [1/1] 1.64e-42    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population European HLA-DRB1 [29/34] rs9268614 (G) [3/3] 3.56e-50    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 3 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European HLA-DRB1 [29/34] rs660895 (G) [1/1] 5.83e-53    / "A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis." Padyukov L, Ann Rheum Dis, 2011 (table 1, sup. table 2). [ Show all associations ] [ PubMed ] 1147 / 1079 Sweden 100% ACPA-positive RA patients from EIRA A control was randomly selected from the study base by matching age, sex and residential area. GWAS: Genome-wide association study. (5) The association data validated by only one genotyping platform and one sample. Illumina 300K chip and imputed SNPs (1723056 SNPs) Among the studies for European population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population Latin American IL2, IL21 [1/1] rs6822844 (-) [1/1] 0.019  0.61  0.06 / 0.10 "Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus." Maiti AK, Arthritis Rheum, 2010 (). [ Show all associations ] [ PubMed ] 354 / 368 Colombia Patients enrolled at the Corporacion para Investigaciones Biolo'gicas in Medellin and the Fundacio'n Cl?'nica Valle de Lili in Cali. All patients with autoimmune diseases met the international classification criteria for their respective disease. Control group for all analyses of Colombian subjects included 368 individuals who did not have a history of chronic inflammatory autoimmune or infectious diseases and were unrelated to the patients. (5) The association data validated by only one genotyping platform and one sample. IL2-IL21 region (1 SNPs) Among the studies for Latin American population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population European FCGR3B [4/6] FCGR3B CN < 2 (2) [2/4] 0.00012  1.67  0.10 / 0.06 "Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples." McKinney C, Ann Rheum Dis, 2010 (Table 2). [ Show all associations ] [ PubMed ] 1702 / 1495 Netherlands, European New Zealand, United Kingdom of Great Britain and Northern Ireland Combined samples from New Zealand (n=606), Dutch (n=741), UK (n=243) and a previous study of Breunis et al (2009, n=112). Combined samples from New Zealand (n=453), Dutch (n=701), UK (n=212) and a previous study of Breunis et al (2009, n=129). (4) The association data validated by different samples FCGR3B copy number was measured using TaqMan Real-Time PCR. (1 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European REL [9/9] rs13031237 (-) [5/5] 1.53e-17  1.21  / "Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population." Eyre S, Ann Rheum Dis, 2010 (figure 1). [ Show all associations ] [ PubMed ] 6566 / 6413 Canada, United Kingdom of Great Britain and Northern Ireland, United States of America Data from Gregersen (2009) and Eyre (2012) Data from Gregersen (2009) and Eyre (2012) (2) The association data validated by different genotyping platforms and different samples. REL (1 SNPs) Among the studies for European population, a statistical significance was confirmed in 5 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian AIRE [7/9] rs2075876 (A) [4/5] 3.6e-09  1.18  0.38 / 0.34 "The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population." Terao C, Hum Mol Genet, 2011 (table 1). [ Show all associations ] [ PubMed ] 5415 / 6489 Japan The case subjects were recruited at the rheumatology departments of Kyoto University Hospital, Dohgo Spa Hospital, Sagamihara National Hospital, Tokyo University Hospital, Tokyo Womenユs Medical University, and Biobank Japan Project. The control subjects were from Aichi Cancer Center Hospital and Research Institute and the Department of Ophthalmology, Visual Science at Kyoto University Hospital, Pharma SNP Consortium, the Center for Genomic Medicine, Graduate School of Medicine, Kyoto University and Biobank Japan Project. (2) The association data validated by different genotyping platforms and different samples. Human-Hap300, Human CNV370-Duo, Human610-Quad, Taqman (2 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 4 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian AIRE [7/9] rs760426 (G) [3/4] 4.4e-08  1.16  0.39 / 0.36 "The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population." Terao C, Hum Mol Genet, 2011 (table 1). [ Show all associations ] [ PubMed ] 5415 / 6489 Japan The case subjects were recruited at the rheumatology departments of Kyoto University Hospital, Dohgo Spa Hospital, Sagamihara National Hospital, Tokyo University Hospital, Tokyo Womenユs Medical University, and Biobank Japan Project. The control subjects were from Aichi Cancer Center Hospital and Research Institute and the Department of Ophthalmology, Visual Science at Kyoto University Hospital, Pharma SNP Consortium, the Center for Genomic Medicine, Graduate School of Medicine, Kyoto University and Biobank Japan Project. (2) The association data validated by different genotyping platforms and different samples. Human-Hap300, Human CNV370-Duo, Human610-Quad, Taqman (2 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population East Asian APOM [3/44] rs805297 (A) [2/2] 6.65e-05  1.40  0.45 / 0.36 "Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis." Hu HJ, Exp Mol Med, 2011 (Sup. Table S1). [ Show all associations ] [ PubMed ] 578 / 711 Republic of Korea RA patients (469 females and 109 males, mean age 53.2 +-12.0 yr). from St. Vincent Hospital, Suwon, Korea and Eulji University Hospital, Korea. 70.7 and 84.4% were RF and anti-CCP positives, respectively. Healthy controls (452 females and 259 males, mean age 52.3 +-12.9 yr) from St. Vincent Hospital, Suwon, Korea and Eulji University Hospital, Korea. (5) The association data validated by only one genotyping platform and one sample. TaqMan analysis (4 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian HLA-DRB1 [23/36] rs2157337 (C) [1/1] 2.6e-118  1.99  0.59 / 0.44 "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 4074 / 16891 Japan The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). GWAM: GWAS Meta analysis. (3) The association data validated by different genotyping platforms. Illumina HumanHap610-Quad BeadChip, Illumina HumanHap300 BeadChip, Illumina Human CNV370-Duo BeadChip, Illumina HumanHap610-Quad BeadChip, Affymetrix Genome-wide Human SNP Array 6.0 (1948139 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian CCR6 [5/8] rs3093023 (A) [1/2] 2.1e-17  1.27  0.52 / 0.46 "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 4074 / 16891 Japan The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). GWAM: GWAS Meta analysis. (3) The association data validated by different genotyping platforms. Illumina HumanHap610-Quad BeadChip, Illumina HumanHap300 BeadChip, Illumina Human CNV370-Duo BeadChip, Illumina HumanHap610-Quad BeadChip, Affymetrix Genome-wide Human SNP Array 6.0 (1948139 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian OLIG3, TNFAIP3 [7/10] rs5029937 (T) [1/1] 3.9e-09  1.33  0.09 / 0.07 "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 4074 / 16891 Japan The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). GWAM: GWAS Meta analysis. (3) The association data validated by different genotyping platforms. Illumina HumanHap610-Quad BeadChip, Illumina HumanHap300 BeadChip, Illumina Human CNV370-Duo BeadChip, Illumina HumanHap610-Quad BeadChip, Affymetrix Genome-wide Human SNP Array 6.0 (1948139 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian SPRED2 [1/2] rs934734 (G) [1/2] 3.2e-07  1.19  0.19 / 0.16 "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 4074 / 16891 Japan The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). The meta-analysis was conducted on three independent GWAS (from the BioBank Japan Project18 with 2,414 rheumatoid arthritis cases and 14,245 controls10, Kyoto University with 1,237 rheumatoid arthritis cases and 2,087 controls12 and IORRA19 with 423 rheumatoid arthritis cases and 559 controls). GWAM: GWAS Meta analysis. (3) The association data validated by different genotyping platforms. Illumina HumanHap610-Quad BeadChip, Illumina HumanHap300 BeadChip, Illumina Human CNV370-Duo BeadChip, Illumina HumanHap610-Quad BeadChip, Affymetrix Genome-wide Human SNP Array 6.0 (1948139 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 2 association results.
The variant is confirmed between different ethnic populations.
Intra-population East Asian NFKBIE [8/8] rs2233434 (G) [8/8] 5.8e-19  1.19  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 8 out of 8 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian ARID5B [4/5] rs10821944 (G) [4/5] 5.5e-18  1.16  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 4 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian PTPN2 [4/8] rs2847297 (G) [3/5] 2.2e-08  1.10  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian B3GNT2 [3/4] rs11900673 (T) [3/4] 1.1e-08  1.11  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian ANXA3 [4/4] rs2867461 (A) [4/4] 1.2e-12  1.13  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 4 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian CD83 [4/4] rs12529514 (C) [4/4] 2e-08  1.14  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 4 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian PRKCB1 [2/4] rs7404928 (T) [2/4] 4e-06  1.08  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian ETS1, FLI1 [3/9] rs4937362 (T) [2/5] 7.5e-07  1.09  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian CSF2 [2/4] rs657075 (A) [2/4] 2.8e-10  1.12  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian PRKCH [3/8] rs1957895 (G) [2/4] 3.6e-07  1.09  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian ZNF774 [2/4] rs6496667 (A) [2/4] 1.4e-06  1.09  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian GCH1 [2/4] rs3783637 (C) [2/4] 2e-06  1.10  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian IRF8 [2/4] rs2280381 (T) [2/4] 2.4e-06  1.12  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian EXOC2, IRF4 [2/4] rs9405675 (A) [2/4] 9.6e-06  1.08  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian PLD4 [3/4] rs2841277 (T) [3/4] 1.9e-14  1.15  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian ARAP1, PDE2A [3/4] rs3781913 (T) [3/4] 5.8e-10  1.12  / "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population." Okada Y, Nat Genet, 2012 (Sup. Table 3). [ Show all associations ] [ PubMed ] 9351 / 38575 Japan (3) The association data validated by different genotyping platforms. - (47 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population European HLA-DRB1 [29/34] rs2157337 (C) [2/2] 1e-299  2.50  0.69 / 0.46 "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci." Stahl EA, Nat Genet, 2010 (Supplementary Table 1A). [ Show all associations ] [ PubMed ] 5539 / 20169 Canada, Sweden, United Kingdom of Great Britain and Northern Ireland, United States of America Cases with CCP positive; from BRASS, CANADA, EIRA, NARAC, WTCCC Controls from BRASS, CANADA, EIRA and WTCCC GWAM: GWAS Meta analysis. (2) The association data validated by different genotyping platforms and different samples. Affymetrix 6.0, Illumina 370K, Illumina 317K, Illumina 500K, Affymetrix 500K (2554714 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population African American IKZF3 [1/1] rs2872507 (G) [1/1] 0.006  0.79  0.71 / 0.76 "Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12." Kurreeman FA, Am J Hum Genet, 2012 (Table 3). [ Show all associations ] [ PubMed ] 440 / 795 United States of America 440 seropositive cases (RF+ or ACPA+) from the CLEAR (Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis) registry 795 controls (kindly provided by Drs. Robert P. Kimberly and Jeffrey C. Edberg) were from either the CLEAR Registry or the Birmingham, Alabama area (5) The association data validated by only one genotyping platform and one sample. Sequenom iPLEX (13 SNPs) Among the studies for African American population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian ZEB1 [1/2] rs2793108 (T) [1/2] 0.001  1.11  0.58 / 0.55 "Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12." Kurreeman FA, Am J Hum Genet, 2012 (Table 3). [ Show all associations ] [ PubMed ] 2414 / 14245 Japan 2414 cases (76% RF+, 79% ACPA+) (5) The association data validated by only one genotyping platform and one sample. Illumina HumanHap610-Quad BeadChip (13 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population East Asian IKZF3 [2/2] rs2872507 (G) [2/2] 0.003  0.91  0.72 / 0.74 "Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12." Kurreeman FA, Am J Hum Genet, 2012 (Table 3). [ Show all associations ] [ PubMed ] 2414 / 14245 Japan 2414 cases (76% RF+, 79% ACPA+) (5) The association data validated by only one genotyping platform and one sample. Illumina HumanHap610-Quad BeadChip (13 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian IL2, IL21 [1/1] rs13119723 (G) [1/1] 0.008  0.75  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian HLA-DRB1 [4/4] rs6910071 (-) [1/1] 0.04  1.27  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian HLA-DRB1 [4/4] rs660895 (G) [1/1] 2.56e-05  1.52  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian HLA-DRB1 [4/4] rs6457617 (A) [1/1] 1.6e-09  1.48  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian HLA-DRB1 [4/4] rs13192471 (G) [1/1] 6.7e-16  2.16  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian IL2RA [4/9] rs2104286 (G) [1/1] 0.00019  0.73  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population South Asian ZEB1 [1/1] rs2793108 (C) [1/1] 0.006  0.84  / "Caucasian and Asian specific rheumatoid arthritis risk loci reveal limited replication and apparent allelic heterogeneity in north Indians." Prasad P, PLoS One, 2012 (Table S1, S2). [ Show all associations ] [ PubMed ] 983 / 1007 India 983 RA cases of north-Indian origin were recruited from the All India Institute of Medical Sciences (AIIMS) and Research and Referral Hospital (R&R), New Delhi based on American College of Rheumatology criteria for RA. 1007 healthy controls which included spouses and healthy staff members (above 35 years of age with no medical history of RA/or any other form of arthritis) of north-Indian origin were recruited from the study hospitals mentioned above and also from Dayanand Medical College & Hospital, Ludhiana. (5) The association data validated by only one genotyping platform and one sample. Infinium Human 660W-quad SNP microarray platform (47 SNPs) Among the studies for South Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population European FCGR3B [4/6] FCGR3B <2 (-) [2/2] 0.004  1.47  / "Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis." Graf SW, Arthritis Res Ther, 2012 (Figure 2). [ Show all associations ] [ PubMed ] 2475 / 2320 European Australia, Germany, European New Zealand, United Kingdom of Great Britain and Northern Ireland, United States of America Cases from Breunis 2009, McKinney 2010, Marques 2010, Mamtani 2010, and this study. Controls from Breunis 2009, McKinney 2010, Marques 2010, Mamtani 2010, and this study. (2) The association data validated by different genotyping platforms and different samples. (1 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population East Asian CTLA4, ICOS [5/7] rs231775 (G) [2/2] 0.002  1.18  / "Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis." Li X, J Clin Immunol, 2012 (Table 5). [ Show all associations ] [ PubMed ] 2734 / 1441 China, Japan, Republic of Korea 7 articles from Lee CS, Lee YH, Lei C, Matsushita M, Takeuchi F, Tsukahara S, Yanagawa T. 7 articles from Lee CS, Lee YH, Lei C, Matsushita M, Takeuchi F, Tsukahara S, Yanagawa T. (2) The association data validated by different genotyping platforms and different samples. (1 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed between different ethnic populations.
Inter-population Latin American CTLA4, ICOS [1/1] rs231775 (G) [1/1] 0.01  1.45  / "Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis." Li X, J Clin Immunol, 2012 (Table 5). [ Show all associations ] [ PubMed ] 199 / 199 Mexico 1 articles from Munoz-Valle J. 1 articles from Munoz-Valle J. (5) The association data validated by only one genotyping platform and one sample. (1 SNPs) Among the studies for Latin American population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population East Asian OLIG3, TNFAIP3 [7/10] rs10499194 (-) [2/3] 0.00067  1.25  / "Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis." Lee YH, Inflamm Res, 2012 (Table 3). [ Show all associations ] [ PubMed ] 4731 / 3332 Japan, Republic of Korea Subjects from Shimane et al. and Han et al. Subjects from Shimane et al. and Han et al. (2) The association data validated by different genotyping platforms and different samples. rs10499194 (1 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population African American OLIG3, TNFAIP3 [1/3] rs2230926 (-) [1/1] 0.032  1.85  / "Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis." Lee YH, Inflamm Res, 2012 (Table 3). [ Show all associations ] [ PubMed ] 148 / 1513 United States of America Subjects from Musone et al. Subjects from Musone et al. (5) The association data validated by only one genotyping platform and one sample. rs2230926 (1 SNPs) Among the studies for African American population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population East Asian CDH6, LOC100128783 [3/4] rs4394137 (C) [3/4] 0.001  1.10  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian MN1 [3/4] rs723184 (T) [3/4] 0.00012  1.12  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 3 out of 4 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian STAT4 [13/18] rs10168266 (A) [4/5] 3.2e-08  1.16  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 4 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian TRPC6 [2/3] rs4520564 (T) [2/3] 0.05  1.05  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian ENOX1 [2/3] rs9533469 (T) [2/3] 1.7e-05  1.19  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian TNFAIP3 [2/4] rs679670 (G) [2/3] 6.1e-06  1.16  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian VPS18 [2/3] rs8024138 (T) [2/3] 1.3e-05  1.19  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian PFKL [2/3] rs4350841 (C) [2/3] 1.4e-06  1.13  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population East Asian RTKN2 [2/3] rs3125734 (T) [2/3] 3.7e-08  1.23  / "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-ƒÈB pathway are associated with rheumatoid arthritis in Japanese." Myouzen K, PLoS Genet, 2012 (Table S2). [ Show all associations ] [ PubMed ] 7890 / 35340 Japan Sujects from BBJP, RIKEN, IORRA and Kyoto university. Sujects from BBJP and Kyoto university. (2) The association data validated by different genotyping platforms and different samples. Illumina HumanHap610-Quad and Taqman genotyping system (31 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 2 out of 3 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European C5, TRAF1 [18/25] rs7026551 (-) [2/2] 2e-08  1.31  / "TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study." Plenge RM, N Engl J Med, 2007 (Table 2). [ Show all associations ] [ PubMed ] 2575 / 3648 North America, Sweden, United States of America Cases from NARAC and EIRA Controls from NARAC and EIRA (2) The association data validated by different genotyping platforms and different samples. TRAF-1-C5 loci SNPs (9 SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 2 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Inter-population East Asian IL6 [1/1] rs1800795 (G) [1/1] 1e-08  0.07  / "The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis." Lee YH, Inflamm Res, 2012 (Table 2). [ Show all associations ] [ PubMed ] 120 / 168 China Result of Huang (2007). Result of Huang (2007). (5) The association data validated by only one genotyping platform and one sample. (2 SNPs) Among the studies for East Asian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Inter-population Iranian IL6 [1/1] rs1800795 (G) [1/1] 7.4e-05  0.46  / "The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis." Lee YH, Inflamm Res, 2012 (Table 2). [ Show all associations ] [ PubMed ] 425 / 247 Turkey Result of Arman (2011). Result of Arman (2011). (5) The association data validated by only one genotyping platform and one sample. (3 SNPs) Among the studies for Iranian population, a statistical significance was confirmed in 1 out of 1 association results.
The variant is confirmed between different ethnic populations.
Intra-population European PTPRC [2/6] rs10919563 (G) [2/6] 6.27e-06    / "" (). [ Show all associations ] [ PubMed ] / ( SNPs) Among the studies for European population, a statistical significance was confirmed in 2 out of 6 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.
Intra-population European MMEL1, TNFRSF14 [8/8] rs3890745 (T) [5/5] 5.28e-07    / "" (). [ Show all associations ] [ PubMed ] / ( SNPs) Among the studies for European population, a statistical significance was confirmed in 5 out of 5 association results.
The variant is confirmed by more than one independent studies in the specific ethnic population.