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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000268722 Accession number: CR541852 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Proteasome assembly chaperone 1; PAC-1; Chromosome 21 leucine-rich protein; C21-LRP; Down syndrome critical region protein 2;
 
 

Transcript original information
Accession number CR541852.1
CAGE tag ID NA
EST ID NA
Clone Number RZPDo834E0432D
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (PSMG1) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (PSMG1);
Sequence data provider NA
Annotation project NA
Length of cDNA 864[bp] (No. of exon:7)[A:252 T:228 G:210 C:174]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature C-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0016114
Genomic location  G-integra Help Chromosome 21
Location 21q22.2
Position 40547519- 40555311
Strand -
Possible duplicated location(s) NA
Gene structure 7 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8624
KEGG GENES KEGG GENES(8624)
GeneCard GeneCardPSMG1*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000023577
Predicted CDS 1..864;  288[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.692

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000268722
H-Inv cluster ID Locus viewHIX0016114
Accession number CR541852.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Proteasome assembly chaperone 1; PAC-1; Chromosome 21 leucine-rich protein; C21-LRP; Down syndrome critical region protein 2;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (O95456)  [Identity/coverage = 99.653%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 978438010830953108728201548933415590417156707751625196917707236190548511960886121269460ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol PSMG1
HGNC aliases "Down syndrome critical region gene 2"
HGNC name proteasome (prosome, macropain) assembly chaperone 1
DDBJ DSCR2
UniProt PSMG1
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000023577
No. of interaction 5
Interaction partner(s) HIP000050362HIP000050362HIP000136553HIP000147735HIP000207843
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8624
KEGG GENES KEGG GENES(8624)
GeneCard GeneCardPSMG1*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT cytosol;  nuclear;  cytoskeleton;  extracellular; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA130123; 
Affymetrix
GeneChip
HG-Focus 203405_at; 
HG-U133 203405_at; 
HG-U133A 203405_at; 
HG-U133A_2 203405_at; 
HG-U133B NA
HG-U133_Plus_2 203405_at; 
HG-U95 36088_at; 
HG-U95A 36088_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3921312;  3921314;  3932133;  3932135;  3932136;  3932138;  3932139;  3932140;  3932142;  3932143;  3932144; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
38 .. 38 C/T rs150047855 - CDS Nonsynonymous[Pro13Leu]
116 .. 116 T/C rs1127135 + CDS Nonsynonymous[Leu39Pro]
117 .. 117 G/C rs1127136 + CDS Synonymous[Leu39Leu]
131 .. 131 A/T rs200000347 - CDS Nonsynonymous[Lys44Met]
177 .. 177 A/T rs139346791 - CDS Nonsynonymous[Glu59Asp]
178 .. 178 G/C rs147961251 - CDS Nonsynonymous[Val60Leu]
201 .. 201 G/A rs142099337 - CDS Synonymous[Pro67Pro]
206 .. 206 C/T rs138957098 - CDS Nonsynonymous[Ser69Phe]
221 .. 221 C/T rs139461009 - CDS Nonsynonymous[Ala74Val]
242 .. 242 C/G rs200021987 - CDS Nonsynonymous[Ala81Gly]
263 .. 263 T/C rs78317549 - CDS Nonsynonymous[Met88Thr]
266 .. 266 A/C rs187341087 - CDS Nonsynonymous[Asn89Thr]
270 .. 270 A/T rs201325737 - CDS Synonymous[Ser90Ser]
291 .. 291 T/C rs141146603 - CDS Synonymous[Gly97Gly]
297 .. 297 C/T rs3171465 + CDS Synonymous[Ala99Ala]
317 .. 317 G/A rs183446739 - CDS Nonsynonymous[Cys106Tyr]
323 .. 323 C/T rs143749424 - CDS Nonsynonymous[Thr108Ile]
371 .. 371 A/G rs149520065 - CDS Nonsynonymous[Tyr124Cys]
386 .. 386 A/G rs200278874 - CDS Nonsynonymous[Asn129Ser]
408 .. 408 G/T rs138014655 - CDS Nonsynonymous[Gln136His]
417 .. 417 C/T rs201716985 - CDS Synonymous[Cys139Cys]
419 .. 419 A/G rs200670808 - CDS Nonsynonymous[Tyr140Cys]
429 .. 429 A/T rs145581162 - CDS Nonsynonymous[Glu143Asp]
496 .. 496 A/G rs8131611 - CDS Nonsynonymous[Ile166Val]
504 .. 504 A/G rs61750772 - CDS Synonymous[Thr168Thr]
510 .. 510 A/G rs138817199 - CDS Synonymous[Arg170Arg]
524 .. 524 A/T rs145022066 - CDS Nonsynonymous[Tyr175Phe]
602 .. 602 C/T rs113955862 - CDS Nonsynonymous[Ala201Val]
603 .. 603 G/A rs140933529 - CDS Synonymous[Ala201Ala]
612 .. 612 A/G rs200983810 - CDS Synonymous[Pro204Pro]
632 .. 632 T/C rs202176293 - CDS Nonsynonymous[Ile211Thr]
634 .. 634 G/A rs200756272 - CDS Nonsynonymous[Val212Ile]
650 .. 650 C/G rs148120925 - CDS Nonsynonymous[Ala217Gly]
681 .. 681 A/C rs143701237 - CDS Nonsynonymous[Lys227Asn]
687 .. 687 A/G rs14194 + CDS Synonymous[Pro229Pro]
828 .. 828 G/C rs34970037 - CDS Nonsynonymous[Leu276Phe]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer